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Author: VINCENT OKONKWO AND CHIOMA AWUZIE
VINCENT OKONKWO PH.D IS A LECTURER IN THE DEPARTMENT OF SCIENCE LABORATORY TECHNOLOGY: FEDERAL POLYTECHNIC OKO,: Email: nwaforvince@gmail.com, CHIOMA AWUZIE, PH.D. WORKS WITH RENEWABLE ENERGY UNIT,, FEDERAL POLYTECHNIC OKO,: Email: nwaforvince@gmail.com
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UTILIZATION OF POROUS POLYMERIC SUBSTRATE WITH PARTICLE FILLERS IN MATRIX ASSISTED LASER DESORPTION AND IONIZATION OF MOLECULES IN MASS SPECTROMETRY


Abstract:

The present research is directed to method for the analysis of various compositions in particular those utilizing high-energy desorption and ionization of samples. The substrate made in accordance with the research typically have a porous surface and include one or more surface coatings and particulate fillers. The substrate comprises of high density polyethylene (HDPE) which has carbon based filler. The graphite-loaded MPF was used with Diamond like glasses (DLG) spots to analyze prozasin, a class of medicine called anti-hypertensive and neurotensin, on the other hand, is an endogenous trideca-peptide neurotransmitter. The series of eight molecules were dissolved individually in methanol in concentration ranges from 0.1 to 0.3 µg/ µL. Samples were labeled A through H. 1.0µL of each solution was spotted into the MPF and air-dried. Testing was done with and without DLG coatings. A matrix was not used. The test results using the graphite had films are shown in Table 2. The LDI mass spectra for prazosin without DLG (S5) and with DLG S7 are shown in figs 2a and 2b. The LDI mass spectra for neurotensin without DLG (S6) and with DLG (S8) as shown in figs 3a and 3b respectively. This technique can be used to verify the molecular weight of low molecular weight molecules in the positive and negative ionization modes in the absence of matrix. The sensitivity and reproducibility of this technique were further confirmed by analyzing a mixture of four of the compounds at different concentrations. The resolution and signal to noise ratio of the testing of the eight compounds as shown in table 4 is an empirical evidence.



ATTENTION!: GLOBAL COMMUNICATOR JOURNAL VOLUME 3 ISSUE 1, JUNE 2018 HAS BEEN PUBLISHED.
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Published in Volume 3 Issue 1, June 2018. 533 Views and Downloads
Paper's Reference Code:
GC655
Keywords: desorption, ionization, fragmentation, gas-phase ions, matrix, fillers, resolution

No. of published submissions by VINCENT OKONKWO AND CHIOMA AWUZIE is 1
 











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